A collection of high-difficulty questions regarding human physiology, pharmacology, and pathology.
This article details a case study of a 63-year-old man who achieved long-term HIV-1 remission after an allogeneic hematopoietic stem cell transplant (HSCT) from a sibling donor with a specific genetic mutation (CCR5Δ32/Δ32). The study provides in-depth virological and immunological analyses, including the absence of intact HIV DNA and replication-competent virus, and highlights the significance of donor chimerism in various tissues for achieving a potential cure.
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