Question 1

As the pK of an acid increases, what happens to its strength?

Accepted Answer

Decreases

Question 2

What is the primary factor to consider when identifying the most acidic proton in a molecule?

Accepted Answer

The stability of the negative charge on the conjugate base

Question 3

Which of the following factors contributes to the stabilization of a negative charge on a conjugate base, thereby increasing the acidity of the parent acid?

Accepted Answer

Resonance

Question 4

According to the text, acidity increases when moving in which direction across a row of the periodic table?

Accepted Answer

Left to right

Question 5

How do inductive effects from electron-withdrawing groups influence the acidity of an acid?

Accepted Answer

They increase acidity.

Question 6

What is the effect of increased S-character in the hybridization of the atom carrying a negative charge on the conjugate base, in terms of acidity?

Accepted Answer

It increases acidity.

Question 7

In the given structural comparison, which proton is identified as the most acidic?

Accepted Answer

Hc

Question 8

Why is Hc considered the most acidic proton in the provided example?

Accepted Answer

The negative charge is stabilized by resonance and located on oxygen.

Question 9

Compared to Ha and Hb, why is the conjugate base of Hc more stable?

Accepted Answer

The charge is on oxygen and stabilized by resonance.

Question 10

Which of the following is NOT listed as a factor that can stabilize the charge on a conjugate base and increase acidity?

Accepted Answer

Steric hindrance

Question 11

The text states that the acidity increases down a column of the periodic table. This is related to which factor?

Accepted Answer

Type of element

Question 12

If a conjugate base is resonance stabilized, what is the effect on the acidity of the parent acid?

Accepted Answer

Acidity increases.

Question 13

In the comparison of Ha, Hb, and Hc, which proton is the least acidic?

Accepted Answer

Ha

Question 14

The hybridization of the atom carrying the negative charge on the conjugate base for Ha is described as:

Accepted Answer

sp

Question 15

What does the notation 'A⁻' represent in the context of an acid 'HA'?

Accepted Answer

The conjugate base of the acid

Acid Strength and Conjugate Base Stability

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