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Hard Genetics Fact-Check

Genetics

A series of precise questions focusing on dates, numerical data, and historical figures in the field of genetics.

science biology genetics history hard
25 Questions Hard Ages 16+ Sep 20, 2026

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About this Study Set

This study set covers Genetics through 25 practice questions. A series of precise questions focusing on dates, numerical data, and historical figures in the field of genetics. Every question includes the correct answer so you can learn as you go — pick any format above to get started.

Questions & Answers

Browse all 25 questions from the Hard Genetics Fact-Check study set below. Each question shows the correct answer — select a study format above to practice interactively.

1 In which year did Oswald Avery, Colin MacLeod, and Maclyn McCarty publish their paper proving that DNA is the substance that causes bacterial transformation?
  • A 1944
  • B 1952
  • C 1941
  • D 1953
2 How many base pairs are contained in the approximate haploid human genome length as determined by the Human Genome Project?
  • A 2.5 billion
  • B 3.2 billion
  • C 4.1 billion
  • D 1.8 billion
3 Barbara McClintock was awarded the Nobel Prize in Physiology or Medicine in 1983 for the discovery of what genetic phenomenon, first observed in the 1940s?
  • A Epigenetic imprinting
  • B Transposable elements
  • C Alternative splicing
  • D Telomere shortening
4 The Hershey-Chase experiment, which confirmed DNA as the genetic material using bacteriophages, was conducted in which year?
  • A 1950
  • B 1953
  • C 1952
  • D 1948
5 What is the exact number of chromosomes typically found in a normal human diploid somatic cell?
  • A 48
  • B 44
  • C 46
  • D 23
6 In Gregor Mendel's 1866 paper 'Experiments on Plant Hybridization', how many distinct pea plant traits did he meticulously document and cross-breed?
  • A 5
  • B 7
  • C 9
  • D 12
7 James Watson and Francis Crick published their seminal paper on the double-helix structure of DNA in the journal Nature on what specific date?
  • A April 25, 1953
  • B February 28, 1953
  • C May 15, 1953
  • D March 7, 1953
8 How many codons are there in the standard genetic code?
  • A 20
  • B 64
  • C 48
  • D 128
9 The first genetically modified organism, a bacterium resistant to antibiotics, was created by Herbert Boyer and Stanley Cohen in which year?
  • A 1971
  • B 1973
  • C 1975
  • D 1979
10 Frederick Sanger developed the chain-termination method for DNA sequencing in which year?
  • A 1977
  • B 1980
  • C 1974
  • D 1982
11 What is the total number of amino acids standardly encoded by the genetic code for protein synthesis?
  • A 22
  • B 20
  • C 18
  • D 24
12 In 1902, Walter Sutton proposed the Chromosomal Theory of Inheritance; in which year did Theodor Boveri independently arrive at similar conclusions?
  • A 1902
  • B 1904
  • C 1906
  • D 1908
13 The International Human Genome Sequencing Consortium officially announced the completion of the 'finished' version of the human genome sequence in what year?
  • A 2001
  • B 2003
  • C 2005
  • D 2007
14 How many hydrogen bonds are present between a Guanine-Cytosine base pair in DNA?
  • A 1
  • B 2
  • C 3
  • D 4
15 Marshall Nirenberg and Heinrich Matthaei identified the first codon (UUU for phenylalanine) in which year?
  • A 1961
  • B 1959
  • C 1963
  • D 1965
16 What is the approximate percentage of the human genome that consists of coding sequences (exons)?
  • A 1.5%
  • B 5%
  • C 10%
  • D 20%
17 The enzyme DNA polymerase I was first isolated by Arthur Kornberg in which year?
  • A 1955
  • B 1957
  • C 1959
  • D 1961
18 In humans, the mitochondrial genome consists of how many base pairs?
  • A 16,569
  • B 12,450
  • C 20,100
  • D 8,200
19 Which scientist discovered the 'transforming principle' in Streptococcus pneumoniae in 1928?
  • A Oswald Avery
  • B Frederick Griffith
  • C Alfred Hershey
  • D Martha Chase
20 The polymerase chain reaction (PCR) technique was invented by Kary Mullis in which year?
  • A 1981
  • B 1983
  • C 1985
  • D 1987
21 Thomas Hunt Morgan won the Nobel Prize in 1933 for his work on which model organism?
  • A Caenorhabditis elegans
  • B Drosophila melanogaster
  • C Mus musculus
  • D Arabidopsis thaliana
22 How many rings does a purine base have in its chemical structure?
  • A 1
  • B 2
  • C 3
  • D 4
23 In 1941, George Beadle and Edward Tatum proposed the 'one gene-one enzyme' hypothesis based on experiments with which organism?
  • A Neurospora crassa
  • B Saccharomyces cerevisiae
  • C Escherichia coli
  • D Zea mays
24 The Human Genome Project was officially launched by the U.S. government in which year?
  • A 1988
  • B 1990
  • C 1992
  • D 1994
25 How many stop codons exist in the standard genetic code?
  • A 1
  • B 2
  • C 3
  • D 4
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