About this Study Set
This study set covers Biochemistry through
20 practice questions.
An advanced set of questions focusing on the numerical, chronological, and nomenclatural foundations of biochemistry. Every question includes the correct answer so you can learn as you go — pick any format above to get started.
Questions & Answers
Browse all 20 questions from the
Biochemistry Historical and Quantitative Milestones study set below.
Each question shows the correct answer — select a study format above to practice interactively.
1
In what year did James B. Sumner publish his definitive proof that the enzyme urease is a protein, thereby settling a long-standing debate?
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A
1926
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B
1932
-
C
1940
-
D
1918
2
The first crystal structure of a protein, myoglobin, was determined by John Kendrew and Max Perutz in which year?
-
A
1953
-
B
1958
-
C
1962
-
D
1948
3
How many carbon atoms are present in the core structure of a steroid nucleus (gonane)?
4
The complete human mitochondrial genome consists of approximately how many base pairs?
-
A
12,500
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B
16,569
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C
22,400
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D
8,200
5
The term 'biochemistry' (Biochemie) was first coined by which German chemist in 1903?
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A
Carl Neuberg
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B
Eduard Buchner
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C
Hermann Emil Fischer
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D
Frederick Gowland Hopkins
6
What is the standard free energy change (delta G'°) for the hydrolysis of phosphoenolpyruvate (PEP) in kJ/mol?
-
A
-30.5
-
B
-42.3
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C
-61.9
-
D
-14.8
7
At a pH of 7.4, what is the approximate net charge of a molecule of the amino acid histidine (pKa of imidazole group is ~6.0)?
8
The 'Central Dogma' of molecular biology was first articulated by Francis Crick in what year?
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A
1953
-
B
1957
-
C
1961
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D
1965
9
How many turns are found in a standard B-DNA double helix that contains 105 base pairs?
-
A
10.5
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B
9.5
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C
11.0
-
D
10.0
10
Who was awarded the 1907 Nobel Prize in Chemistry for his discovery of cell-free fermentation?
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A
Eduard Buchner
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B
Arthur Harden
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C
Hans von Euler-Chelpin
-
D
Otto Warburg
11
In the standard genetic code, how many of the 64 possible codons are classified as 'stop' codons?
12
The peptide hormone insulin consists of two chains connected by how many interchain disulfide bridges?
13
What is the approximate molecular weight (in kDa) of a single subunit of the E. coli RNA polymerase core enzyme (beta subunit)?
-
A
151 kDa
-
B
95 kDa
-
C
43 kDa
-
D
110 kDa
14
The Henderson-Hasselbalch equation was derived by Lawrence Joseph Henderson in 1908 and later modified by Karl Hasselbalch in what year?
-
A
1910
-
B
1912
-
C
1916
-
D
1920
15
How many ATP molecules are consumed in the priming phase of glycolysis per molecule of glucose?
16
Which vitamin is chemically known as pteroylmonoglutamic acid?
17
The average molecular weight of an amino acid residue in a protein is considered to be approximately how many Daltons?
18
How many high-energy phosphate bonds are broken to activate an amino acid for protein synthesis via aminoacyl-tRNA synthetase?
19
Frederick Sanger determined the full amino acid sequence of bovine insulin in which year?
-
A
1945
-
B
1953
-
C
1958
-
D
1962
20
The Michaelis constant (Km) is numerically equivalent to the substrate concentration at which the reaction velocity is what fraction of Vmax?
